Ultrastructural Study in Canine Prostatic Hyperplasia
نویسندگان
چکیده
Chlormadinone acetate (CMA) and cyproterone acetate have been used in medicaltreatment of human benign prostatic hyperplasia (BPH) or prostatic carcinoma [2,3,8,9]. The atrophic effects of CMA on the prostate of rats and dogs have been previously reported from our laboratory[5,6]. Using spontaneous BPH dogs we found that immunostaining of androgen receptor (AR) in both epithelial and stromal fibro-muscular cell nuclei was remarkably decreased by CMA treatment[7], which may be attributed to the decrease in the number of AR and /or antibody binding sites for AR. Therefore, we postulated that atrophy of the prostate after treatment with CMA is the result of effects not only on the epithelium but on the stroma. This report mainly deals with the ultrastructural changes in canine prostates (spontaneous BPH) after treatment with CMA. MATERIALS AND METHODS
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